Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

Systematic exploration of cancer cell vulnerabilities can inform the development of novel cancer therapeutics. Here, through analysis of genome-scale loss-of-function datasets, we identify adenosine deaminase acting on RNA (ADAR or ADAR1) as an essential gene for the survival of a subset of cancer c...

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Publié dans:Nat Commun
Auteurs principaux: Gannon, Hugh S., Zou, Tao, Kiessling, Michael K., Gao, Galen F., Cai, Diana, Choi, Peter S., Ivan, Alexandru P., Buchumenski, Ilana, Berger, Ashton C., Goldstein, Jonathan T., Cherniack, Andrew D., Vazquez, Francisca, Tsherniak, Aviad, Levanon, Erez Y., Hahn, William C., Meyerson, Matthew
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6303303/
https://ncbi.nlm.nih.gov/pubmed/30575730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07824-4
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