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Synthetic substrate analogs for the RNA-editing adenosine deaminase ADAR-2.

We have synthesized structural analogs of a natural RNA editing substrate and compared editing reactions of these substrates by recombinant ADAR-2, an RNA-editing adenosine deaminase. Deamination rates were shown to be sensitive to structural changes at the 2[prime]-carbon of the edited adenosine. M...

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Udgivet i:Nucleic Acids Res
Principais autores: Yi-Brunozzi, H Y, Easterwood, L M, Kamilar, G M, Beal, P A
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1999
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148506/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10390533/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.14.2912
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