Synthetic substrate analogs for the RNA-editing adenosine deaminase ADAR-2.
We have synthesized structural analogs of a natural RNA editing substrate and compared editing reactions of these substrates by recombinant ADAR-2, an RNA-editing adenosine deaminase. Deamination rates were shown to be sensitive to structural changes at the 2[prime]-carbon of the edited adenosine. M...
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| Veröffentlicht in: | Nucleic Acids Res |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
1999
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| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148506/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10390533/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.14.2912 |
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