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Pathogenic Protein Seeding in Alzheimer’s Disease and Other Neurodegenerative Disorders

The misfolding and aggregation of specific proteins is a seminal occurrence in a remarkable variety of neurodegenerative disorders. In Alzheimer’s disease (the most prevalent cerebral proteopathy), the two principal aggregating proteins are β-amyloid (Aβ) and tau. The abnormal assemblies formed by c...

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Autori principali: Jucker, Mathias, Walker, Lary C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203752/
https://ncbi.nlm.nih.gov/pubmed/22028219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.22615
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