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Unexpected Binding Modes of Nitric Oxide Synthase Inhibitors Effective in the Prevention of Cerebral Palsy Phenotype in an Animal Model

Selective inhibition of the neuronal isoform of nitric oxide synthase NOS (nNOS) has been shown to prevent brain injury and is important for the treatment of various neurodegenerative disorders. However, given the high active site conservation among all three NOS isoforms, the design of selective in...

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Bibliografiske detaljer
Main Authors: Delker, Silvia L, Ji, Haitao, Li, Huiying, Jamal, Joumana, Fang, Jianguo, Xue, Fengtian, Silverman, Richard B., Poulos, Thomas L.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202968/
https://ncbi.nlm.nih.gov/pubmed/20337441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja910228a
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