Pharmacogenetic Trial of a Cannabinoid Agonist Shows Reduced Fasting Colonic Motility in Patients with Non-Constipated Irritable Bowel Syndrome

BACKGROUND: Cannabinoid receptors are located on cholinergic neurons. Genetic variants that affect endocannabinoid metabolism are associated with colonic transit in patients with irritable bowel syndrome with diarrhea (IBS-D). We compared the effects of dronabinol, a non-selective agonist of the can...

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Hlavní autoři: Wong, Banny S., Camilleri, Michael, Busciglio, Irene, Carlson, Paula, Szarka, Lawrence A., Burton, Duane, Zinsmeister, Alan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202649/
https://ncbi.nlm.nih.gov/pubmed/21803011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.07.036
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