Chenodeoxycholate in Females With Irritable Bowel Syndrome-Constipation: A Pharmacodynamic and Pharmacogenetic Analysis

BACKGROUND & AIMS: Sodium chenodeoxycholate (CDC) accelerates colonic transit in health. Our aim was to examine pharmacodynamics (colonic transit, bowel function) and pharmacogenetics of CDC in constipation-predominant irritable bowel syndrome (IBS-C). METHODS: In a double-blind placebo-controll...

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Autori principali: RAO, ARCHANA S., WONG, BANNY S., CAMILLERI, MICHAEL, ODUNSI-SHIYANBADE, SUWEBATU T., MCKINZIE, SANNA, RYKS, MICHAEL, BURTON, DUANE, CARLSON, PAULA, LAMSAM, JESSE, SINGH, RAVINDER, ZINSMEISTER, ALAN R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189402/
https://ncbi.nlm.nih.gov/pubmed/20691689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.07.052
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