Pharmacogenetics of the Effects of Colesevelam on Colonic Transit in Irritable Bowel Syndrome with Diarrhea

BACKGROUND: Protein products of klothoβ (KLB) and fibroblast growth factor receptor 4 (FGFR4) impact fibroblast growth factor 19-mediated feedback inhibition of hepatic bile acid (BA) synthesis. Variants of KLB and FGFR4 influence colonic transit (CT) in diarrhea-predominant irritable bowel syndrome...

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Main Authors: Wong, Banny S., Camilleri, Michael, Carlson, Paula J., Odunsi-Shiyanbade, Suwebatu, McKinzie, Sanna, Busciglio, Irene, Burton, Duane, Zinsmeister, Alan R.
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809827/
https://ncbi.nlm.nih.gov/pubmed/22271411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10620-012-2035-5
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