Randomized Pharmacodynamic and Pharmacogenetic Trial of Dronabinol Effects on Colon Transit in Irritable Bowel Syndrome-Diarrhea

BACKGROUND: Genetic variation in endocannabinoid metabolism is associated with colonic transit in irritable bowel syndrome (IBS) with diarrhea (IBS-D). The nonselective cannabinoid (CB) receptor agonist, dronabinol (DRO), reduced fasting colonic motility in nonconstipated IBS. FAAH and CNR1 variants...

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Hlavní autoři: Wong, Banny S., Camilleri, Michael, Eckert, Deborah, Carlson, Paula, Ryks, Michael, Burton, Duane, Zinsmeister, Alan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775711/
https://ncbi.nlm.nih.gov/pubmed/22288893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2982.2011.01874.x
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