Pharmacogenetics of Low Dose Clonidine in Irritable Bowel Syndrome

OBJECTIVES: Adrenergic and serotonergic (ADR-SER) mechanisms alter gut (GI) sensorimotor functions. We aimed to determine whether candidate ADR-SER genes affect GI responses to low dose clonidine (CLO) in humans. METHODS: Forty healthy and 120 irritable bowel syndrome (IBS) participants received CLO...

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Bibliographic Details
Main Authors: Camilleri, Michael, Busciglio, Irene, Carlson, Paula, McKinzie, Sanna, Burton, Duane, Baxter, Kari, Ryks, Michael, Zinsmeister, Alan R.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2690641/
https://ncbi.nlm.nih.gov/pubmed/19309415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2982.2009.01263.x
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