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PPARα activation promotes macrophage reverse cholesterol transport through an LXR-dependent pathway

OBJECTIVE: Peroxisome proliferator-activate receptorα (PPARα) activation has been shown in vitro to increase macrophage cholesterol efflux, the initial step in reverse cholesterol transport (RCT). However, it remains unclear whether PPARα activation promotes macrophage RCT in vivo. METHODS AND RESUL...

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Bibliografiske detaljer
Main Authors: Nakaya, Kazuhiro, Tohyama, Junichiro, Naik, Snehal U, Tanigawa, Hiroyuki, Jaye, Michael, MacPhee, Colin, Billheimer, Jeffrey T, Rader, Daniel J
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202300/
https://ncbi.nlm.nih.gov/pubmed/21441141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.225383
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