Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport

Phospholipid transfer protein (PLTP) may affect macrophage reverse cholesterol transport (mRCT) through its role in the metabolism of HDL. Ex vivo cholesterol efflux capacity and in vivo mRCT were assessed in PLTP deletion and PLTP overexpression mice. PLTP deletion mice had reduced HDL mass and cho...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Kuwano, Takashi, Bi, Xin, Cipollari, Eleonora, Yasuda, Tomoyuki, Lagor, William R., Szapary, Hannah J., Tohyama, Junichiro, Millar, John S., Billheimer, Jeffrey T., Lyssenko, Nicholas N., Rader, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392748/
https://ncbi.nlm.nih.gov/pubmed/28137768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M074625
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