PPARα activation promotes macrophage reverse cholesterol transport through an LXR-dependent pathway

OBJECTIVE: Peroxisome proliferator-activate receptorα (PPARα) activation has been shown in vitro to increase macrophage cholesterol efflux, the initial step in reverse cholesterol transport (RCT). However, it remains unclear whether PPARα activation promotes macrophage RCT in vivo. METHODS AND RESUL...

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Detalhes bibliográficos
Main Authors: Nakaya, Kazuhiro, Tohyama, Junichiro, Naik, Snehal U, Tanigawa, Hiroyuki, Jaye, Michael, MacPhee, Colin, Billheimer, Jeffrey T, Rader, Daniel J
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202300/
https://ncbi.nlm.nih.gov/pubmed/21441141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.225383
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