PPARγ activation redirects macrophage cholesterol from fecal excretion to adipose tissue uptake in mice via SR-BI

PPARγ agonists, used in the treatment of Type 2 diabetes, can raise HDL-cholesterol, therefore could potentially stimulate macrophage-to-feces reverse cholesterol transport (RCT). We aimed to test whether PPARγ activation promotes macrophage RCT in vivo. Macrophage RCT was assessed in mice using cho...

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Main Authors: Toh, Sue-Anne, Millar, John S., Billheimer, Jeffrey, Fuki, Ilia, Naik, Snehal U., Macphee, Colin, Walker, Max, Rader, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315103/
https://ncbi.nlm.nih.gov/pubmed/21291868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2011.01.012
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