Identification of Direct Target Engagement Biomarkers for Kinase-Targeted Therapeutics

Pharmacodynamic (PD) biomarkers are an increasingly valuable tool for decision-making and prioritization of lead compounds during preclinical and clinical studies as they link drug-target inhibition in cells with biological activity. They are of particular importance for novel, first-in-class mechan...

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Main Authors: Paweletz, Cloud P., Andersen, Jannik N., Pollock, Roy, Nagashima, Kumiko, Hayashi, Mansuo L., Yu, Shangshuan U., Guo, Hongbo, Bobkova, Ekaterina V., Xu, Zangwei, Northrup, Alan, Blume-Jensen, Peter, Hendrickson, Ronald C., Chi, An
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3200335/
https://ncbi.nlm.nih.gov/pubmed/22039492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026459
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