Sensitive multiplexed analysis of kinase activities and activity-based kinase identification

Constitutive activation of one or more kinase signaling pathways is a hallmark of many cancers. Here we extend the previously described mass spectrometry–based KAYAK approach by monitoring kinase activities from multiple signaling pathways simultaneously. This improved single-reaction strategy, whic...

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Main Authors: Kubota, Kazuishi, Anjum, Rana, Yu, Yonghao, Kunz, Ryan C, Andersen, Jannik N, Kraus, Manfred, Keilhack, Heike, Nagashima, Kumiko, Krauss, Stefan, Paweletz, Cloud, Hendrickson, Ronald C, Feldman, Adam S, Wu, Chin-Lee, Rush, John, Villén, Judit, Gygi, Steven P
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129615/
https://ncbi.nlm.nih.gov/pubmed/19801977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1566
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