A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors

BACKGROUND: Hyperactivation of the Ras signaling pathway is a driver of many cancers, and RAS pathway activation can predict response to targeted therapies. Therefore, optimal methods for measuring Ras pathway activation are critical. The main focus of our work was to develop a gene expression signa...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Loboda, Andrey, Nebozhyn, Michael, Klinghoffer, Rich, Frazier, Jason, Chastain, Michael, Arthur, William, Roberts, Brian, Zhang, Theresa, Chenard, Melissa, Haines, Brian, Andersen, Jannik, Nagashima, Kumiko, Paweletz, Cloud, Lynch, Bethany, Feldman, Igor, Dai, Hongyue, Huang, Pearl, Watters, James
التنسيق: Artigo
اللغة:Inglês
منشور في: BioMed Central 2010
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911390/
https://ncbi.nlm.nih.gov/pubmed/20591134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-3-26
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