Human 1-Acylglycerol-3-phosphate O-Acyltransferase Isoforms 1 and 2: BIOCHEMICAL CHARACTERIZATION AND INABILITY TO RESCUE HEPATIC STEATOSIS IN Agpat2(−/−) GENE LIPODYSTROPHIC MICE

Loss-of-function mutations in 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) 2 in humans and mice result in loss of both the white and brown adipose tissues from birth. AGPAT2 generates precursors for the synthesis of glycerophospholipids and triacylglycerols. Loss of adipose tissue, or lipody...

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Hauptverfasser: Agarwal, Anil K., Sukumaran, Suja, Cortés, Víctor A., Tunison, Katie, Mizrachi, Dario, Sankella, Shireesha, Gerard, Robert D., Horton, Jay D., Garg, Abhimanyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Lipids
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199511/
https://ncbi.nlm.nih.gov/pubmed/21873652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.250449
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