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Hepatic Gluconeogenesis Is Enhanced by Phosphatidic Acid Which Remains Uninhibited by Insulin in Lipodystrophic Agpat2(−/−) Mice

In this study we examined the role of phosphatidic acid (PA) in hepatic glucose production (HGP) and development of hepatic insulin resistance in mice that lack 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2). Liver lysophosphatidic acid and PA levels were increased ∼2- and ∼5-fold, respecti...

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Autores principales: Sankella, Shireesha, Garg, Abhimanyu, Horton, Jay D., Agarwal, Anil K.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931038/
https://ncbi.nlm.nih.gov/pubmed/24425876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.530998
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