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Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2(−/−) lipodystrophic mice independent of hepatocyte leptin receptors
Leptin is essential for energy homeostasis and regulation of food intake. Patients with congenital generalized lipodystrophy (CGL) due to mutations in 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2) and the CGL murine model (Agpat2(−/−) mice) both have severe insulin resistance, diabetes mel...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The American Society for Biochemistry and Molecular Biology
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3886666/ https://ncbi.nlm.nih.gov/pubmed/24293639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M045799 |
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