Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2(−/−) lipodystrophic mice independent of hepatocyte leptin receptors

Leptin is essential for energy homeostasis and regulation of food intake. Patients with congenital generalized lipodystrophy (CGL) due to mutations in 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2) and the CGL murine model (Agpat2(−/−) mice) both have severe insulin resistance, diabetes mel...

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Bibliografiske detaljer
Main Authors: Cortés, Víctor A., Cautivo, Kelly M., Rong, Shunxing, Garg, Abhimanyu, Horton, Jay D., Agarwal, Anil K.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2014
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3886666/
https://ncbi.nlm.nih.gov/pubmed/24293639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M045799
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