Human 1-Acylglycerol-3-phosphate O-Acyltransferase Isoforms 1 and 2: BIOCHEMICAL CHARACTERIZATION AND INABILITY TO RESCUE HEPATIC STEATOSIS IN Agpat2(−/−) GENE LIPODYSTROPHIC MICE

Loss-of-function mutations in 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) 2 in humans and mice result in loss of both the white and brown adipose tissues from birth. AGPAT2 generates precursors for the synthesis of glycerophospholipids and triacylglycerols. Loss of adipose tissue, or lipody...

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Detalhes bibliográficos
Main Authors: Agarwal, Anil K., Sukumaran, Suja, Cortés, Víctor A., Tunison, Katie, Mizrachi, Dario, Sankella, Shireesha, Gerard, Robert D., Horton, Jay D., Garg, Abhimanyu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199511/
https://ncbi.nlm.nih.gov/pubmed/21873652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.250449
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