Human 1-Acylglycerol-3-phosphate O-Acyltransferase Isoforms 1 and 2: BIOCHEMICAL CHARACTERIZATION AND INABILITY TO RESCUE HEPATIC STEATOSIS IN Agpat2(−/−) GENE LIPODYSTROPHIC MICE

Loss-of-function mutations in 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) 2 in humans and mice result in loss of both the white and brown adipose tissues from birth. AGPAT2 generates precursors for the synthesis of glycerophospholipids and triacylglycerols. Loss of adipose tissue, or lipody...

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Detaylı Bibliyografya
Asıl Yazarlar: Agarwal, Anil K., Sukumaran, Suja, Cortés, Víctor A., Tunison, Katie, Mizrachi, Dario, Sankella, Shireesha, Gerard, Robert D., Horton, Jay D., Garg, Abhimanyu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2011
Konular:
Lipids
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199511/
https://ncbi.nlm.nih.gov/pubmed/21873652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.250449
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