Human 1-Acylglycerol-3-phosphate O-Acyltransferase Isoforms 1 and 2: BIOCHEMICAL CHARACTERIZATION AND INABILITY TO RESCUE HEPATIC STEATOSIS IN Agpat2(−/−) GENE LIPODYSTROPHIC MICE

Loss-of-function mutations in 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) 2 in humans and mice result in loss of both the white and brown adipose tissues from birth. AGPAT2 generates precursors for the synthesis of glycerophospholipids and triacylglycerols. Loss of adipose tissue, or lipody...

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Détails bibliographiques
Auteurs principaux: Agarwal, Anil K., Sukumaran, Suja, Cortés, Víctor A., Tunison, Katie, Mizrachi, Dario, Sankella, Shireesha, Gerard, Robert D., Horton, Jay D., Garg, Abhimanyu
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Lipids
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199511/
https://ncbi.nlm.nih.gov/pubmed/21873652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.250449
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