Discovery of Isoxazole Analogs of Sazetidine-A as Selective α4β2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists for the Treatment of Depression

Depression, a common neurological condition, is one of the leading causes of disability and suicide worldwide. Standard treatment targeting monoamine transporters selective for the neurotransmitters serotonin and noradrenalin are not able to help many patients that are poor responders. This study ad...

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Autori principali: Liu, Jianhua, Yu, Li-Fang, Eaton, J. Brek, Caldarone, Barbara, Cavino, Katie, Ruiz, Christina, Terry, Matthew, Fedolak, Allison, Wang, Daguang, Ghavami, Afshin, Lowe, David A., Brunner, Dani, Lukas, Ronald J., Kozikowski, Alan P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197876/
https://ncbi.nlm.nih.gov/pubmed/21905669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200855b
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