Pluripotency factor binding and Tsix expression act synergistically to repress Xist in undifferentiated embryonic stem cells

BACKGROUND: Expression of Xist, the master regulator of X chromosome inactivation, is extinguished in pluripotent cells, a process that has been linked to programmed X chromosome reactivation. The key pluripotency transcription factors Nanog, Oct4 and Sox2 are implicated in Xist gene extinction, at...

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Hlavní autoři: Nesterova, Tatyana B, Senner, Claire E, Schneider, Janina, Alcayna-Stevens, Tilly, Tattermusch, Anna, Hemberger, Myriam, Brockdorff, Neil
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197471/
https://ncbi.nlm.nih.gov/pubmed/21982142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8935-4-17
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