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Pluripotency factor binding and Tsix expression act synergistically to repress Xist in undifferentiated embryonic stem cells
BACKGROUND: Expression of Xist, the master regulator of X chromosome inactivation, is extinguished in pluripotent cells, a process that has been linked to programmed X chromosome reactivation. The key pluripotency transcription factors Nanog, Oct4 and Sox2 are implicated in Xist gene extinction, at...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3197471/ https://ncbi.nlm.nih.gov/pubmed/21982142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8935-4-17 |
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