Cross-Clade HIV-1 Neutralizing Antibodies Induced with V3-Scaffold Protein Immunogens following Priming with gp120 DNA

The V3 epitope is a known target for HIV-1 neutralizing antibodies (NAbs), and V3-scaffold fusion proteins used as boosting immunogens after gp120 DNA priming were previously shown to induce NAbs in rabbits. Here, we evaluated whether the breadth and potency of the NAb response could be improved whe...

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Detalhes bibliográficos
Main Authors: Zolla-Pazner, Susan, Kong, X.-P., Jiang, Xunqing, Cardozo, Timothy, Nádas, Arthur, Cohen, Sandra, Totrov, Maxim, Seaman, Michael S., Wang, Shixia, Lu, Shan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196418/
https://ncbi.nlm.nih.gov/pubmed/21795338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05086-11
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