Rationally Designed Immunogens Targeting HIV-1 gp120 V1V2 Induce Distinct Conformation-Specific Antibody Responses in Rabbits

The V1V2 region of HIV-1 gp120 harbors a major vulnerable site targeted by a group of broadly neutralizing monoclonal antibodies (MAbs) such as PG9 through strand-strand recognition. However, this epitope region is structurally polymorphic as it can also form a helical conformation recognized by RV1...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Jiang, Xunqing, Totrov, Max, Li, Wei, Sampson, Jared M., Williams, Constance, Lu, Hong, Wu, Xueling, Lu, Shan, Wang, Shixia, Zolla-Pazner, Susan, Kong, Xiang-Peng
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2016
Sujets:
Vaccines and Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5126360/
https://ncbi.nlm.nih.gov/pubmed/27707920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01409-16
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