Structure-guided design and immunological characterization of immunogens presenting the HIV-1 gp120 V3 loop on a CTB scaffold

V3 loop is a major neutralizing determinant of the HIV-1 gp120. Using 3D structures of cholera toxin B subunit (CTB), complete V3 in the gp120 context and V3 bound to a monoclonal antibody (mAb) we designed two V3-scaffold immunogen constructs (V3-CTB). The full-length V3-CTB presenting the complete...

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Hlavní autoři: Totrov, Maxim, Jiang, Xunqing, Kong, Xiang-Peng, Cohen, Sandra, Krachmarov, Chavdar, Williams, Constance, Seaman, Michael S., Cardozo, Timothy, Gorny, Miroslaw K, Wang, Shixia, Lu, Shan, Pinter, Abraham, Zolla-Pazner, Susan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2942080/
https://ncbi.nlm.nih.gov/pubmed/20663531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.06.027
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