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New Aporphinoid 5-HT(2A) and α(1A) Antagonists via Structural Manipulations of Nantenine
A series of C1, C2, C3 and N6 analogs of nantenine (2) was synthesized and evaluated in 5-HT(2A) and α(1A) receptor functional assays. Alkyl substitution of the C1 and N6 methyl groups of nantenine provided selective 5-HT(2A) and α(1A) antagonists respectively. The C2 alkyloxy analogs studied were g...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3196372/ https://ncbi.nlm.nih.gov/pubmed/21900013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.08.019 |
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