New Aporphinoid 5-HT(2A) and α(1A) Antagonists via Structural Manipulations of Nantenine

A series of C1, C2, C3 and N6 analogs of nantenine (2) was synthesized and evaluated in 5-HT(2A) and α(1A) receptor functional assays. Alkyl substitution of the C1 and N6 methyl groups of nantenine provided selective 5-HT(2A) and α(1A) antagonists respectively. The C2 alkyloxy analogs studied were g...

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Autori principali: Ponnala, Shashikanth, Chaudhary, Sandeep, LeGendre, Onica, Gonzales, Junior A., Navarro, Hernán A., Harding, Wayne W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196372/
https://ncbi.nlm.nih.gov/pubmed/21900013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.08.019
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