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(±)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners

C1 and flexible analogs of (±)-nantenine were synthesized and evaluated for antagonist activity at human 5-HT(2A) receptors in a calcium mobilization assay. This work has resulted in the identification of the most potent 5-HT(2A) antagonist known based on an aporphine. Our results also suggest that...

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Autors principals: Chaudhary, Sandeep, Pecic, Stevan, LeGendre, Onica, Navarro, Hérnan A., Harding, Wayne W.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677726/
https://ncbi.nlm.nih.gov/pubmed/19328689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.03.048
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