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(±)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners
C1 and flexible analogs of (±)-nantenine were synthesized and evaluated for antagonist activity at human 5-HT(2A) receptors in a calcium mobilization assay. This work has resulted in the identification of the most potent 5-HT(2A) antagonist known based on an aporphine. Our results also suggest that...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2677726/ https://ncbi.nlm.nih.gov/pubmed/19328689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.03.048 |
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