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Synthetic studies and pharmacological evaluations on the MDMA (“Ecstasy”) antagonist Nantenine
The naturally occurring aporphine alkaloid nantenine, has been shown to antagonize behavioral and physiological effects of MDMA in mice. We have synthesized (±)-nantenine via an oxidative cyclization reaction with PIFA and evaluated its binding profile against a panel of CNS targets. To begin to und...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818532/ https://ncbi.nlm.nih.gov/pubmed/19963380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.11.053 |
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