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Nantenine as an acetylcholinesterase inhibitor: SAR, enzyme kinetics and molecular modeling investigations
Nantenine, as well as a number of flexible analogs, were evaluated for acetylcholinesterase (AChE) inhibitory activity in microplate spectrophotometric assays based on Ellman’s method. It was found that the rigid aporphine core of nantenine is an important structural requirement for its anticholines...
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| Publicado no: | J Enzyme Inhib Med Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4663080/ https://ncbi.nlm.nih.gov/pubmed/20583856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/14756361003671078 |
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