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APORPHINOID ANTAGONISTS OF 5-HT(2A) RECEPTORS: FURTHER EVALUATION OF RING A SUBSTITUENTS AND THE SIZE OF RING C
A series of ring A modified analogs of nantenine as well as structural variants in ring C were synthesized and evaluated for antagonist activity at 5-HT(2A) and α(1A) receptors. Halogenation improves 5-HT(2A) antagonist potency in molecules containing a C1 methoxyl/C2 methoxyl or C1 methoxyl/C2 hydr...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4197079/ https://ncbi.nlm.nih.gov/pubmed/24766771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12345 |
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