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Synthesis and evaluation of aporphine analogues containing C1 allyl isosteres at the h5-HT(2A) receptor
A series of C1 aporphine analogues related to compound 5 and that contain substituted allylic, alkynyl, nitrile, ester and benzyl groups was synthesized and evaluated for affinity at h5HT(2A) and α(1A) receptors in functional activity assays that measure calcium release. The presence of branched all...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4628873/ https://ncbi.nlm.nih.gov/pubmed/26475518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.10.012 |
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