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C4 phenyl aporphines with selective h5-HT(2B) receptor affinity
A group of aporphine alkaloids related to (±)-nantenine (1) and bearing a C4 phenyl and various C1 or N-substituents, was synthesized and evaluated for affinity to h5-HT receptors. In general, unlike nantenine, the analogues lack affinity for the h5-HT(2A) receptor and other 5-HT receptors but bind...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4523491/ https://ncbi.nlm.nih.gov/pubmed/26227772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.07.012 |
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