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Synthesis and evaluation of aporphine analogues containing C1 allyl isosteres at the h5-HT(2A) receptor

A series of C1 aporphine analogues related to compound 5 and that contain substituted allylic, alkynyl, nitrile, ester and benzyl groups was synthesized and evaluated for affinity at h5HT(2A) and α(1A) receptors in functional activity assays that measure calcium release. The presence of branched all...

詳細記述

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書誌詳細
出版年:Bioorg Med Chem Lett
主要な著者: Ponnala, Shashikanth, Kapadia, Nirav, Madapa, Sudharshan, Alberts, Ian L., Harding, Wayne W.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4628873/
https://ncbi.nlm.nih.gov/pubmed/26475518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.10.012
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