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The structure of a tetrahydrofolate sensing riboswitch reveals two ligand binding sites in a single aptamer
Transport and biosynthesis of folate and its derivatives is frequently controlled by the tetrahydrofolate (THF) riboswitch in Firmicutes. We have solved the crystal structure of the THF riboswitch aptamer in complex with folinic acid, a THF analog. Uniquely, this structure reveals two molecules of f...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3196276/ https://ncbi.nlm.nih.gov/pubmed/21906956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.06.019 |
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