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Adaptive ligand binding by the purine riboswitch in the recognition of guanine and adenine analogs
Purine riboswitches discriminate between guanine and adenine by at least 10,000-fold based on the identity of a single pyrimidine (Y74) that forms a Watson-Crick base pair with the ligand. To understand how this high degree of specificity for closely related compounds is achieved through simple pair...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2721690/ https://ncbi.nlm.nih.gov/pubmed/19523903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.04.009 |
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