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The structure of a tetrahydrofolate sensing riboswitch reveals two ligand binding sites in a single aptamer

Transport and biosynthesis of folate and its derivatives is frequently controlled by the tetrahydrofolate (THF) riboswitch in Firmicutes. We have solved the crystal structure of the THF riboswitch aptamer in complex with folinic acid, a THF analog. Uniquely, this structure reveals two molecules of f...

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書誌詳細
主要な著者: Trausch, Jeremiah J., Ceres, Pablo, Reyes, Francis E., Batey, Robert T.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196276/
https://ncbi.nlm.nih.gov/pubmed/21906956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.06.019
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