Nucleotides Adjacent to the Ligand-Binding Pocket are Linked to Activity Tuning in the Purine Riboswitch

Direct sensing of intracellular metabolite concentrations by riboswitch RNAs provides an economical and rapid means to maintain metabolic homeostasis. Since many organisms employ the same class of riboswitch to control different genes or transcription units, it is likely that functional variation ex...

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Hauptverfasser: Stoddard, Colby D., Widmann, Jeremy, Trausch, Jeremiah J., Marcano-Velázquez, Joan G., Knight, Rob, Batey, Robert T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769107/
https://ncbi.nlm.nih.gov/pubmed/23485418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.02.023
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