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A disconnect between high affinity binding and efficient regulation by antifolates and purines in the tetrahydrofolate (THF) riboswitch
The tetrahydrofolate (THF) riboswitch regulates folate transport and metabolism in a number of Firmicutes by cooperatively binding two molecules of THF. To further understand this riboswitch’s specificity for THF, binding and regulatory activity of a series of THF analogs and antifolates was examine...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3935398/ https://ncbi.nlm.nih.gov/pubmed/24388757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.11.012 |
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