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The structure of a tetrahydrofolate sensing riboswitch reveals two ligand binding sites in a single aptamer

Transport and biosynthesis of folate and its derivatives is frequently controlled by the tetrahydrofolate (THF) riboswitch in Firmicutes. We have solved the crystal structure of the THF riboswitch aptamer in complex with folinic acid, a THF analog. Uniquely, this structure reveals two molecules of f...

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Detalhes bibliográficos
Main Authors: Trausch, Jeremiah J., Ceres, Pablo, Reyes, Francis E., Batey, Robert T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196276/
https://ncbi.nlm.nih.gov/pubmed/21906956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.06.019
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