Influence of the Hepatic Eukaryotic Initiation Factor 2α (eIF2α) Endoplasmic Reticulum (ER) Stress Response Pathway on Insulin-mediated ER Stress and Hepatic and Peripheral Glucose Metabolism

Recent studies have implicated endoplasmic reticulum (ER) stress in insulin resistance associated with caloric excess. In mice placed on a 3-day high fat diet, we find augmented eIF2α signaling, together with hepatic lipid accumulation and insulin resistance. To clarify the role of the liver ER stre...

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Detalhes bibliográficos
Main Authors: Birkenfeld, Andreas L., Lee, Hui-Young, Majumdar, Sachin, Jurczak, Michael J., Camporez, Joao Paulo, Jornayvaz, Francois R., Frederick, David W., Guigni, Blas, Kahn, Mario, Zhang, Dongyang, Weismann, Dirk, Arafat, Ayman M., Pfeiffer, Andreas F., Lieske, Stefanie, Oyadomari, Seiichi, Ron, David, Samuel, Varman T., Shulman, Gerald I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196114/
https://ncbi.nlm.nih.gov/pubmed/21832042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.228817
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