Combined Treatment with the Mood Stabilizers Lithium and Valproate Produces Multiple Beneficial Effects in Transgenic Mouse Models of Huntington's Disease

Emerging evidence suggests that the mood stabilizers lithium and valproate (VPA) have broad neuroprotective and neurotrophic properties, and that these occur via inhibition of glycogen synthase kinase 3 (GSK-3) and histone deacetylases (HDACs), respectively. Huntington's disease (HD) is an inhe...

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Autores principales: Chiu, Chi-Tso, Liu, Guangping, Leeds, Peter, Chuang, De-Maw
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2011
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3194069/
https://ncbi.nlm.nih.gov/pubmed/21796107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.128
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