Combined Treatment with the Mood Stabilizers Lithium and Valproate Produces Multiple Beneficial Effects in Transgenic Mouse Models of Huntington's Disease

Emerging evidence suggests that the mood stabilizers lithium and valproate (VPA) have broad neuroprotective and neurotrophic properties, and that these occur via inhibition of glycogen synthase kinase 3 (GSK-3) and histone deacetylases (HDACs), respectively. Huntington's disease (HD) is an inhe...

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Bibliographische Detailangaben
Hauptverfasser: Chiu, Chi-Tso, Liu, Guangping, Leeds, Peter, Chuang, De-Maw
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3194069/
https://ncbi.nlm.nih.gov/pubmed/21796107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.128
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