Combined Treatment with the Mood Stabilizers Lithium and Valproate Produces Multiple Beneficial Effects in Transgenic Mouse Models of Huntington's Disease

Emerging evidence suggests that the mood stabilizers lithium and valproate (VPA) have broad neuroprotective and neurotrophic properties, and that these occur via inhibition of glycogen synthase kinase 3 (GSK-3) and histone deacetylases (HDACs), respectively. Huntington's disease (HD) is an inhe...

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Main Authors: Chiu, Chi-Tso, Liu, Guangping, Leeds, Peter, Chuang, De-Maw
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3194069/
https://ncbi.nlm.nih.gov/pubmed/21796107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.128
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