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Delineation of the molecular mechanisms of nucleoside recognition by cytidine deaminase through virtual screening
Cytidine deaminase (3.5.4.5, CDA), an enzyme of the pyrimidine salvage pathways, is responsible for the degradation and inactivation of several cytidine-based antitumoral drugs, such as cytarabine, gemcitabine, decitabine, and azacytidine. Thus, CDA inhibitors are highly sought after as compounds to...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3193038/ https://ncbi.nlm.nih.gov/pubmed/21598398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201100139 |
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