Equilibrative nucleoside transporter 1 genotype, cytidine deaminase activity and age predict gemcitabine plasma clearance in patients with solid tumours

AIM: Gemcitabine (GEM) enters normal and tumour cells via concentrative (CNT) and equilibrative nucleoside transporters (ENT) and is subsequently deaminated to the inactive difluorodeoxyurine (dFdU) by cytidine deaminase (CDA). The aim of our study was to ascertain whether the nucleoside transporter...

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Detalhes bibliográficos
Main Authors: Gusella, Milena, Pasini, Felice, Bolzonella, Caterina, Meneghetti, Silvia, Barile, Carmen, Bononi, Antonio, Toso, Silvia, Menon, Daniela, Crepaldi, Giorgio, Modena, Yasmina, Stievano, Laura, Padrini, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2011
Assuntos:
Pharmacogenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045553/
https://ncbi.nlm.nih.gov/pubmed/21284703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03838.x
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