Equilibrative nucleoside transporter 1 genotype, cytidine deaminase activity and age predict gemcitabine plasma clearance in patients with solid tumours

AIM: Gemcitabine (GEM) enters normal and tumour cells via concentrative (CNT) and equilibrative nucleoside transporters (ENT) and is subsequently deaminated to the inactive difluorodeoxyurine (dFdU) by cytidine deaminase (CDA). The aim of our study was to ascertain whether the nucleoside transporter...

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Detaylı Bibliyografya
Asıl Yazarlar: Gusella, Milena, Pasini, Felice, Bolzonella, Caterina, Meneghetti, Silvia, Barile, Carmen, Bononi, Antonio, Toso, Silvia, Menon, Daniela, Crepaldi, Giorgio, Modena, Yasmina, Stievano, Laura, Padrini, Roberto
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2011
Konular:
Pharmacogenetics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045553/
https://ncbi.nlm.nih.gov/pubmed/21284703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03838.x
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